Temporal Lobe Epilepsy and Matrix Metalloproteinase 9: A tempting relation but negative genetic association
نویسندگان
چکیده
منابع مشابه
Temporal Lobe Epilepsy and Matrix Metalloproteinase 9: A tempting relation but negative genetic association
OBJECTIVE Neuroplasticity can be defined as the ability of the brain to adapt to environmental impacts. These adaptations include synapse formation and elimination, cortical reorganization, and neurogenesis. In epilepsy these mechanisms may become detrimental and contribute to disease progression. It has been proposed that Matrix Metalloproteinase 9 (MMP-9), a proteinase that cleaves extracellu...
متن کاملP8: Temporal Lobe Epilepsy and Mitochondrial Dysfunction
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متن کاملIncreased Expression of Matrix Metalloproteinase-9 in Patients with Temporal Lobe Epilepsy.
AIM The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited. The aim of this study was to assess the expression of MMP-9, MMP-2 and their tissue inhibitors (TIMP-1 and TIMP-2) in patients with temporal lobe epilepsy with hippocampa...
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Background: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies. Methods : In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sc...
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ژورنال
عنوان ژورنال: Seizure
سال: 2010
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2010.05.003